The flight began with a taxiing period from the parking to the runway, which took 11 minutes and covered a distance of 2 nautical miles. The aircraft, a Boeing 737-800, then departed from runway 35L at LIMC Milan Malpensa International Airport. The takeoff distance was 1,578 meters, which was 45% of the runway length. The liftoff speed was 152 knots.

The local weather conditions at the time of departure were characterized by a temperature of 27 degrees Celsius and a wind speed of 7 knots from a direction of 210 degrees. The crosswind component was 5 knots, while the tailwind component was also 5 knots. The aircraft then began its enroute climb, which started overhead LIMC Milan Malpensa International Airport Ferno. The climb took 19 minutes and covered a distance of 118 nautical miles, during which the aircraft ascended from an altitude of 531 meters above sea level to 10,902 meters above sea level, an increase of 10,370.6 meters.

Following the enroute climb, the aircraft entered a level cruise phase, which started 1 mile east of Riolunato. This phase lasted for 40 minutes and covered a distance of 350 nautical miles. The aircraft then began its enroute descent, which started 41 miles northwest of Malfa. The descent took 24 minutes and covered a distance of 122 nautical miles, during which the aircraft descended from an altitude of 10,955 meters above sea level to 599 meters above sea level, a decrease of 10,355.8 meters.

The final approach to runway 05 at LICB Comiso Airport was made from the southwest, with a heading of 50.0 degrees at an altitude of 383 meters above ground level and a distance of 4 nautical miles from the runway threshold. The landing was made on runway 05, which had a length of 2,401 meters. The threshold height was good, and the threshold speed was also good at 143 knots. However, the touchdown speed was a little fast at 140 knots, and the touchdown rate was heavy at -3.4 meters per second. The runway touchdown position was slightly misaligned from the centerline by 5.6 meters.

The local weather conditions at the time of landing were characterized by a temperature of 26 degrees Celsius and a wind speed of 14 knots from a direction of 259 degrees. The crosswind component was 7 knots, while the tailwind component was 12 knots. The total landing distance was 1,199 meters, which was 50% of the runway length. The runway rollout alignment was very good. The taxiing period from the runway to the parking took 3 minutes and covered a distance of less than 1 nautical mile. The total flight distance was 598 nautical miles, and the flight duration was 97 minutes. The aircraft used 4,146 kilograms of fuel during the flight.