The flight began with a departure roll from runway 24 at Gustavo Rojas Pinilla International Airport, where the aircraft, an Airbus A320, took off with a takeoff distance of 967 meters, which accounted for 41% of the runway. The liftoff speed was 152 knots. At the time of departure, the local weather conditions were characterized by a temperature of 16 degrees Celsius and a wind speed of 1 knot from a direction of 270 degrees, resulting in a negligible crosswind and headwind.

As the aircraft climbed, it started its enroute climb 3 miles southwest of San Andres, a location in the Departamento de Archipielago de San Andres, Colombia. The climb was from an altitude of 878 feet above sea level to 26,998 feet above sea level, an increase of 26,121 feet in just 9 minutes, covering a distance of 50 nautical miles. Following the climb, the aircraft entered a level cruise, which started 50 miles southeast of San Andres and lasted for 14 minutes, covering a distance of 105 nautical miles.

The enroute descent began 62 miles northwest of Isla Grande, a location in the Provincia de Colon, Panama. The descent was from an altitude of 27,000 feet above sea level to 5,019 feet above sea level, a decrease of 21,981 feet in 12 minutes, covering a distance of 79 nautical miles. The aircraft then entered another level cruise, which started 9 miles south of Palenque and lasted for 2 minutes, covering a distance of 8 nautical miles.

The final descent began 10 miles north of MPPS La Joya Airport Paso Blanco, a location in the Provincia de Panama, Panama. The descent was from an altitude of 5,019 feet above sea level to 1,082 feet above sea level, a decrease of 3,936 feet in just 3 minutes, covering a distance of 13 nautical miles. The aircraft then began its final approach to runway 21L at MPTO Tocumen International Airport, approaching from the northeast at a heading of 211.0 degrees and at an altitude of 1,033 feet above ground level.

The landing on runway 21L at MPTO Tocumen International Airport was characterized by a runway length of 3,060 meters. The threshold height was slightly above the target, while the threshold speed was well above the target at 152 knots. The touchdown distance was good at 325 meters, but the touchdown speed was fast at 148 knots, resulting in a heavy touchdown rate of -665 feet per minute. The runway touchdown position was misaligned by 11.3 meters from the centerline.

The local weather conditions at the time of landing were characterized by a temperature of 15 degrees Celsius and a wind speed of 1 knot from a direction of 269 degrees, resulting in a negligible crosswind and a headwind of 0 knots. The total landing distance was 908 meters, which accounted for 30% of the runway. The runway rollout alignment was slightly misaligned by 10.5 meters from the centerline.

After landing, the aircraft taxied to the parking area from the runway, taking 7 minutes and covering a distance of less than 1 nautical mile. The total flight distance was 263 nautical miles, and the flight duration was 51 minutes, during which the aircraft used 19 kilograms of fuel.