Departing from Genoa Cristoforo Colombo Airport, the Boeing 737-800 began its journey by taxiing from the parking area to the runway, a process that took approximately 8 minutes and covered a distance of 2 nautical miles. Upon reaching runway 28, the aircraft initiated its departure roll, accelerating down the 1,030-meter stretch that comprised 37% of the runway's length. At a liftoff speed of 146 knots, the aircraft successfully took to the skies, with a local temperature of 17°C and wind conditions of 5 knots at 140°.

As the aircraft climbed away from Genoa, it began its enroute climb, ascending from an initial altitude of 312 meters above sea level to a cruising altitude of 10,431 meters. This climb phase, which lasted 17 minutes, covered a distance of 97 nautical miles and resulted in an altitude increase of 10,119 meters. Following this, the aircraft entered a level cruise phase, maintaining a steady altitude and airspeed for 29 minutes as it covered a distance of 217 nautical miles. The enroute descent phase commenced 80 miles south-west of Ponza, Italy, where the aircraft began its gradual descent from 10,450 meters to 453 meters above sea level, a decrease of 9,997.2 meters in 21 minutes.

Upon reaching the final approach phase, the aircraft began its descent towards runway 07 at Falcone-Borsellino Airport, navigating a heading of 67.0° from the south-west. The aircraft touched down 118 meters beyond the touchdown zone, with a touchdown speed of 129 knots, slightly above the target speed. The touchdown rate was good at -1.0 meters per second, and the runway touchdown alignment was very good. Following the landing, the aircraft taxied to the parking area, a process that took approximately 3 minutes and covered less than 1 nautical mile. The total flight distance was 439 nautical miles, with a total flight time of 79 minutes and a fuel consumption of 3,167 kilograms.