Departing from London Heathrow Airport, the Airbus A380 began its takeoff roll on runway 27R, accelerating to a liftoff speed of 163 kt. The aircraft cleared the runway in 1,913 meters, utilizing 53% of the available length. As it lifted off, the crew encountered a local wind of 8 kt at 249°, resulting in a 3 kt crosswind and an 8 kt headwind.

The enroute climb phase commenced overhead Colnbrook, England, where the aircraft transitioned from a low altitude of 1,116 ft asl to a cruising altitude of 35,788 ft asl, a vertical gain of 34,672 ft in 19 minutes. This climb phase covered a distance of 118 nm. The enroute level cruise phase followed, lasting 676 minutes and spanning 3,003 nm, with the aircraft maintaining a steady altitude 4 miles west of Brecon, Wales. The descent phase began 28 miles east of Mantoloking, New Jersey, where the aircraft descended from 35,378 ft asl to 1,595 ft asl, a decrease of 33,783 ft in 21 minutes, covering 120 nm. A brief level cruise phase occurred overhead Arden, Delaware, lasting 3 minutes and covering 7 nm.

The final approach to runway 09R at Philadelphia International Airport was initiated from the west, with the aircraft maintaining a heading of 76.0° at 4 nm and 1,260 ft agl. The landing was executed with a threshold speed slightly above target at 136 kt, and the touchdown point was 66 m beyond the touchdown zone. The touchdown speed was a little fast at 127 kt, but the touchdown rate was good at -176 fpm. The runway touchdown alignment was very good, but the runway rollout alignment was misaligned by 17.1 m from the centreline. The total landing distance was 1,317 m, utilizing 41% of the available runway length. The total flight distance was 3,254 nm, covering a duration of 437 minutes and consuming 94,192 kg of fuel.